Developmental Neuroscience

Developmental Neuroscience includes the study of the proliferation and differentiation of neurons and the organization of those cells into an integrated functioning nervous system. This includes the study of how major anatomical subdivisions of the nervous system are generated from an unspecified neuroepithelium. For example, by knocking out the hoxa-1 gene in mice it was found that a segment of the hindbrain is absent in the mutant animals. Once the cells of the nervous system have been generated they must choose s fate. Researchers at Utah have discovered that some of the molecules which function in the differentiation of the vertebrate retina can function interchangeably with their Drosophila homologs which determine the fate of cells in the rather different compound eye of insects. Once cell fate has been determined, the nervous system wires itself by sending axons to their target neurons. Research teams at Utah are identifying the key molecules in axonal guidance required by pioneer axons as well as the molecules permitting growth cones to follow nerve fascicles. Finally, a nervous system must select appropriate synapses and eliminate inappropriate connections in order to become a fully functional circuit. Such mechanisms are clearly illustrated in studies of how activity-dependent mechanisms reinforce the proper connectivity in the auditory and visual system.

Faculty doing developmental research and their departmental affiliation are:

A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Name

Department

Research Interest

A-C

Top
Michael Bastiani Biology Development of neuronal connections
Josh Bonkowsky Pediatrics Axon pathfinding and development of basal ganglia; function of language genes in CNS development
Mario R. Capecchi Biology and Human Genetics Gene manipulation in mammalian and other eukaryotic cells
Sophie Caron Biology Sensory representations in the Drosophila brain
Clement Chow Human Genetics Genetic variation, Genomics, ER stress, Disease modifiers
Maureen L. Condic Neurobiology & Anatomy Interactions of sensory neurons with extracellular matrix

D-J

Top
Michael Deans Otolaryngology Mechanisms of sensory system development and cellular morphogenesis
Richard Dorsky Neurobiology & Anatomy Signaling pathways in zebrafish neural cell fate determination
Christopher Gregg Neurobiology & Anatomy Early life programming of molecular pathways and neural circuits related to feeding and foraging behaviors
David J. Grunwald Human Genetics Tissue specification during zebrafish embryogenesis

K-P

Top
Yashar Kalani Neurosurgery Wnt signaling and the Neurovascular Unit, Blood Brain Barrier Biology, Stem cell Biology and Regenerative Medicine, Biology of Vascular Malformations, Neurogenetics, extracellular RNAs in Development and Disease
Anthea Letsou Human Genetics Embryonic Development Neurobiology
Suzanne Mansour Human Genetics Genes involved in inner ear development and function
Shannon J. Odelberg Internal Medicine Molecular basis of regeneration and cellular plasticity
Sungjin Park Neurobiology & Anatomy Signal transduction mechanism in the nervous system focusing on the role of GPI-anchored proteins and their regulatory enzymes on neuron-glia communication

Q-Z

Top
Yukio Saijoh Neurobiology & Anatomy Pattern formation of vertebrates
Oleksandr (Alex) Shcheglovitov Neurobiology & Anatomy Development and function of human synapses in health and disease
Ning Tian Ophthalmology & Visual Sciences Development of retinal synaptic circuitry
Monica Vetter Neurobiology & Anatomy Molecular pathways regulating the genesis and degeneration of neurons in the vertebrate nervous system
Megan E. Williams Neurobiology & Anatomy Molecular mechanisms that regulate synapse formation and specificity of neural circuits
Jun Yang Ophthalmology and Visual Sciences Pathogenetic mechanisms of retinal degeneration and cell biology of photoreceptors
Deborah Yurgelun-Todd Psychiatry Application of MR imaging methods to understand emotional processing and cognitive changes associated with behavioral disorders
A B C D E F G H I J K L M N O P Q R S T U V W X Y Z