Neurobiology of Disease

Not only is behavior and cognition being studied at the basic science level but faculty at Utah are considering these issues in relation to aging and in human diseases, such as Alzheimer's and Parkinson's diseases. For instance, the dopaminergic neurons of the basal ganglia have been implicated in the initiation of voluntary movement. Patients with Parkinson's disease show a marked degeneration of these dopamine cells. One research team has developed encapsulated dopamine releasing cells that can be implanted in brain structures that are dopamine deficient. These efforts may eventually ameliorate the symptoms of Parkinson's disease. Another area of strength at Utah is the study of epilepsy, which ranges from the behavior of specific ion channels to the discovery of new drugs to ameliorate the symptoms of this neurological disease.

Faculty doing research in neurobiological diseases and their departmental affiliation are:

A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Name

Department

Research Interest

A-C

Top
Bala Ambati Ophthalmology & Visual Sciences Ocular Angiogenesis and Corneal Research
Jeffrey Anderson Neuroradiology Neurophysiology of distributed brain networks, brain synchrony, functional connectivity. New fMRI, diffusion tensor, and magnetoencephalography methods for diagnosing and understanding neurological disorders such as multiple sclerosis, autism, and Alzheimer Disease.
Wolfgang Baehr Ophthalmology & Visual Sciences Phototransduction, the retinoid cycle, membrane protein transport in photoreceptors and mouse models for inherited retinal disease
Paul S. Bernstein Ophthalmology & Visual Sciences Biochemistry and biophysics of nutritional interventions against ocular disease; carotenoid and omega-3 fatty acid metabolism and function in the human retina; genetics of macular and retina dystrophies and degenerations
Josh Bonkowsky Pediatrics Axon pathfinding and development of basal ganglia; function of language genes in CNS development
KC Brennan Neurology Optical and electrophysiological investigation of the basic mechanisms of migraine
Mario R. Capecchi Biology and Human Genetics Modeling neuropsychiatric disorders in the mouse
Clement Chow Human Genetics Genetic variation, Genomics, ER stress, Disease modifiers
Gregory A. Clark Bioengineering Electrophysiological, cellular, and computational analyses of neuronal plasticity in simple systems (Aplysia and Hermissenda); neural information processing; bio-based neuroprostheses  
Donnell J. Creel Ophthalmology & Visual Sciences Sensory anomalies associated with hypopigmentation and diagnostic use of electrophysiological tests in patients  

D-F

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Anna Docherty Psychiatry Psychiatric genetics
"Chuck" Alan Dorval Bioengineering Neuropathophysioloy, Translational Neuroscience, Neuromodulation, Neuronal Semiotic
Ed Dudek Neurosurgery Mechanisms of neuronal communication under normal developmental conditions and in models of epilepsy using electrophysiological techniques in brain slices as well as in behaving animals
Annette E. Fleckenstein School of Dentistry Neuropharmacology, neurochemistry and aminergic transporters
Jeanne Frederick Ophthalmology & Visual Sciences Investigating the pathogenesis of mutant protein expression in retina neurons
Robert S. Fujinami Pathology Neuroimmunology/Neurovirology - Understanding immune and viral contributions to the pathogenesis of multiple sclerosis and epilepsy

G- J

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Christopher Gregg Neurobiology & Anatomy Early life programming of molecular pathways and neural circuits related to feeding and foraging behaviors
David J. Grunwald Human Genetics Tissue specification during zebrafish embryogenesis
Glen R. Hanson Pharmacology & Toxicology Interaction between neuropeptide and biogenic amine transmitter systems in the central nervous system
Mary Hartnett Ophthalmology & Visual Sciences Mechanisms of vascular genesis, dysgenesis and reorganization in retina
Randy Jensen Neurosurgery Neurosurgical Oncology. Hypoxia and angiogenesis in brain tumors, calcium channel antagonist mediated growth inhibition of brain tumors. Brain tumor biomarker discovery. Animal models of brain tumors and imaging pseudo progression
Bryan W. Jones Ophthalmology & Visual Sciences Retinal circuitry/connectomics and neural plasticity in retinal disease

K-L

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Yashar Kalani Neurosurgery Wnt signaling and the Neurovascular Unit, Blood Brain Barrier Biology, Stem cell Biology and Regenerative Medicine, Biology of Vascular Malformations, Neurogenetics, extracellular RNAs in Development and Disease
Kristen A. Keefe Pharmacology & Toxicology Pharmacology of neurological and neuropsychiatric disorders, including drug abuse and addiction. Normal and pathological functions of the basal ganglia
Richard D. King Neurology Using advanced neuroimaging analysis tools to study morphometric changes in the brain associated with neurodegenerative diseases
Julie R. Korenberg Pediatrics Genetics, neurobiology and multiscale imaging of neural circuitry for disorders of social behavior, animal and human models
Thomas E. Lane Pathology Neural Stem Cells, Multiple Sclerosis, Virology
Anthea Letsou Human Genetics Embryonic Development Neurobiology
Alan R. Light Anesthesiology Neurobiology of pain and fatigue enhancement caused by injury and in Chronic Fatigue and Fibromyalgia syndromes

M-R

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Suzanne Mansour Human Genetics Genes involved in inner ear development and function
Robert E. Marc Ophthalmology & Visual Sciences Retinal Connectomics, Neural Rewiring and Gene Therapy for Neurodegenerative Disease
J. Michael McIntosh Psychiatry and Biology Molecular Pharmacology of CNS receptors and ion channels
Brian J. Mickey Psychiatry Neuroscience of mood disorders
Baldomero M. Olivera Biology Ion channels, membrane receptors and sensory transduction
Sungjin Park Neurobiology & Anatomy Signal transduction mechanism in the nervous system focusing on the role of GPI-anchored proteins and their regulatory enzymes on neuron-glia communication
Stefan-M. Pulst Neurology Inherited diseases of the nervous system with an emphasis on spinocerebellar ataxias and Parkinson's disease
Perry F. Renshaw Psychiatry In vivo neurochemical changes associated with mood and drug abuse disorders; natural products as novel treatments
Scott W. Rogers Neurobiology & Anatomy Molecular biology and neurobiology of ligand-activated receptors

S-T

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Michael C. Sanguinetti Physiology Ionic basis of cardiac excitability; mechanisms of ion channel gating; mechanisms of channel block by drugs
Oleksandr (Alex) Shcheglovitov Neurobiology & Anatomy Development and function of human synapses in health and disease
Jason Shepherd Neurobiology & Anatomy Synaptic plasticity, memory encoding, experience-dependent plasticity in visual cortex and neurological disorders
Patrick A. Tresco Bioengineering CNS Response to Implanted Materials

U-Z

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Monica Vetter Neurobiology & Anatomy Molecular pathways regulating the genesis and degeneration of neurons in the vertebrate nervous system
Peter J. West Pharmacology & Toxicology Neuropharmacology of synaptic plasticity, learning, and memory in epilepsy, Alzheimer's disease, and Down syndrome
John A. White Bioengineering Hippocampal neurophysiology, computational neuroscience, real-time instrumentation  
Karen S. Wilcox Pharmacology & Toxicology Electrophysiological mechanisms of action of novel anticonvulsant drugs
Megan E. Williams Neurobiology & Anatomy Molecular mechanisms that regulate synapse formation and specificity of neural circuits
Jun Yang Ophthalmology and Visual Sciences Pathogenetic mechanisms of retinal degeneration and cell biology of photoreceptors
Deborah Yurgelun-Todd Psychiatry Application of MR imaging methods to understand emotional processing and cognitive changes associated with behavioral disorders
A B C D E F G H I J K L M N O P Q R S T U V W X Y Z