JAMES W. GIBB

Jim Gibb

e-mail: James.Gibb@pharm.utah.edu
Professor Emeritus of Pharmacology and Toxicology

Cellular Neuroscience
B.S. 1958, M.S. 1961, University of Alberta; Ph.D. 1965, University of Michigan

RESEARCH:

Neurotransmission in the brain

Dr. Gibb's investigates neurotransmission in the brain; in particular , he studies synthesis and metabolism of dopamine, 5-hydroxytryptamine and the neuropeptides. Since amphetamines alter the brain concentration of these substances, these drugs are used to perturb these central neurotransmitters. Alterations in the regulation of tyrosine hydroxylase and tryptophan hydroxylase, as well as the metabolism of their respective transmitters, provide valuable information concerning the interrelationships of these neurotransmitters in normal and pathologic states. Given in large doses, which simulate drug abuse conditions, amphetamines are neurotoxic to both dopaminergic and serotenergic nerve terminals. Elucidating the mechanism(s) of this neurotoxicity has application in understanding neurodegenerative diseases, psychiatric illness and drug abuse.

Selected Publications:

Fleckenstein, A.E., Volz T.J. Riddle, E.L., Gibb, J.W., Hanson. G.R. (2007) New insights into the mechanism of action of amphetamines. Ann. Rev. Pharmacol. Toxicol., 47:681-698.

Rau, K.S., Birdsall, E., Baucum, A.J., Adair, B.P., Bitter, R., Gibb, J.W., Hanson, G.R., Fleckenstein, A.E. (2006) Methamphetamine administration reduces hippocampal VMAT-2. J. Pharmacol. Exp. Ther., 318:676-682.

Rau, K.S., Birdsall, E., Hanson, J.E., Johnson-Davis, K.L., Carroll, F.I., Wilkins, D.G., Gibb, J.W., Hanson, G.R., and Fleckenstein, A.E. (2005) Bupropion increases striatal vesicular monoaminetransport. Neuropharmacol, Nov;49(6):820-830.

Truong, J.G., Wilkins, D.G., Baudys, J., Crouch, D.J., Johnson-Davis, K.L., Gibb, J.W., Hanson, G.R. and Fleckenstein, A.E. (2005) Age-dependent methamphetamine-induced alterations in vesicular monoamine transporter-2 function: Implications for neurotoxicity. J. Pharmacol. Exp. Ther., 314:1087-1092.

Brown, J.M., Riddle, E.L., Sandoval, V., Weston, R.K., Hanson, J.E., Crosby, M.J., Ugarte, Y.V., Gibb, J.W. Hanson, G.R. and Fleckenstein, A.E. (2002) A single methamphetamine administration rapidly decreases vesicular dopamine uptake. J. Pharmacol. Exp. Ther., 302:497-501.

Hansen, J.P., Riddle, E.L., Sandoval, V., Brown, J.M., Gibb, J.W., Hanson, G.R. and Fleckenstein, A.E. (2002) Methylenedioxymethamphetamine decreases plasmalemmal and vesicular dopamine transport: Mechanisms and implications for neurotoxicity. J. Pharmacol. Exper. Ther., 300:1093-1100.

Metzger, R.R., Hanson, G.R. Gibb, J.W. and Fleckenstein, A.E. (1998) 3-4-Methylenedioxymethamphetamine-induced acute changes in dopamine transporter function. Eur. J. Pharmacol., 349:205-210.

Fleckenstein, A.E., Metzger, R.R., Gibb, J.W., and Hanson, G.R. (1997) A rapid and reversible change in dopamine transporters induced by methamphetamine. Eur. J. Pharmacol., 323:R9-R10.

Gygi, M.P., Gibb, J.W., and Hanson, G.R. (1996) Methcathinone: An initial study of its effects on monoaminergic systems. J. Pharmacol. Exp. Ther., 276:1066-1072.

Che, S., Johnson, M., Hanson, G.R., and Gibb, J.W. (1995) Body temperature effect on methylenedioxymethamphetamine-induced acute decrease in tryptophan hydroxylase activity. Eur. J. Pharmacol., 293:447-453.

Johnson, M., Sonsalla, P., Letter, A., Hanson, G.R., and Gibb, J.W. (1994) Role of the 5-HT2 receptor in the methamphetamine-induced neurochemical alterations. J. Pharmacol. and Exp. Ther., 270:97-103.