JANET E. LAINHART

Janet Lainhart
e-mail: janet.lainhart@hsc.utah.edu
Associate Professor of Psychiatry and Pediatrics

Faculty, Utah Brain Istitute
Neurobiology of Disease
Brain and Behavior
Developmental Neurobiology
B.S. 1975, Michigan State University; M.D. 1979, Wayne State University School of Medicine. Postgraduate training in Pediatrics and Psychiatry, 1979-1984, 1987-1990, The Johns Hopkins University School of Medicine

RESEARCH:

Neurobiology of autism

Dr. Lainhart's research focuses on understanding brain growth, development, and maturation in autism from the fetal period into adulthood. She leads a multidisciplinary research group that is conducting a longitudinal neuroimaging study of the brain in autism. High-resolution structural MRI, diffusion tensor MRI, functional MRI, fetal ultrasound, and birth and early childhood head circumference data are integrated with clinical and neuropsychological data. The goals are to define brain phenotypes of autism from the prenatal period into adulthood and understand how changes in brain structure and function and white matter microstructure are related to clinical symptoms, course, and outcome. The research is funded by the National Institutes of Mental Health.

Selected Publications:

Anderson, J.S., Druzgal, T.J., Froehlich A., Dubray M.B., Lange N., Alexander A.L., Abildskov T., Nielsen J.A., Cariello A.N., Cooperrider J.R., Bigler E.D., Lainhart J.E. Decreased Interhemispheric Functional Connectivity in Autism. Cereb Cortex, Oct 12. [Epub ahead of print]

Lange, N., DuBray, M.B., Lee J.E., Froimowitz M.P., Froehlich A., Adluru N., Wright B., Ravichandran C., Fletcher P.T., Bigler E.D., Alexander A.L., Lainhart J.E. (2010) Atypical diffusion tensor hemispheric asymmetry: a potential DTI biomarker for autism. Autism Res, 3(6):350-358.

Anderson J.S., Lange N., Froehlich A., DuBray M.B., Druzgal T.J., Froimowitz M.P., Alexander A.L., Bigler E.D., and Lainhart J.E. (2010) Decreased left posterior insular activity during auditory language in autism. AJNR Am J Neuroradiol, 31:131-139.

Lange, N., Froimowitz, M.P., Bigler, E.D., and Lainhart, J.E. (2010) Associations between IQ, total and regional brain volumes, and demography in a large normative sample of healthy children and adolescents. Dev Neuropsychol, 35:296-317.

Bigler, E.D., Abildskov, T.J., Petrie, J.A., Johnson, M., Lange, N., Chipman, J., Lu, J., McMahon, W., and Lainhart, J.E. (2010) Volumetric and voxel-based morphometry findings in autism subjects with and without macrocephaly. Dev Neuropsychol, 35:278-295.

Fletcher, P.T., Whitaker, R.T., Tao, R., DuBray, M.B., Froehlich, A., Ravichandran, C., Alexander, A.L., Bigler, E.D., Lange, N., and Lainhart, J.E. (2010) Microstructural connectivity of the arcuate fasciculus in adolescents with high-functioning autism. Neuroimage, 51:1117-1125.

Mazefsky, C.A., Folstein, S.E., and Lainhart, J.E. (2008) Overrepresentation of mood and anxiety disorders in adults with autism and their first-degree relatives: what does it mean? Autism Res, 1:193-197.

Cleavinger, H.B., Bigler, E.D., Johnson, J.L., Lu, J., McMahon, W., and Lainhart, J.E. (2008) Quantitative magnetic resonance image analysis of the cerebellum in macrocephalic and normocephalic children and adults with autism. J Int Neuropsychol Soc, 14:401-413.

Alexander, A.L., Lee, J.E., Lazar, M., Boudos, R., DuBray, M.B., Oakes, T.R., Miller, J.N., Lu, J., Jeong, E.K., McMahon, W.M., Bigler, E.D., and Lainhart, J.E. (2007) Diffusion tensor imaging of the corpus callosum in Autism. Neuroimage, 34:61-73.

Hobbs, K., Kennedy, A., DuBray, M., Bigler, E.D., Petersen, P.B., McMahon, W., and Lainhart, J.E. (2007) A retrospective fetal ultrasound study of brain size in autism. Biol Psychiatry, 62:1048-1055.

Lee, J.E., Bigler, E.D., Alexander, A.L., Lazar, M., DuBray, M.B., Chung, M.K., Johnson, M., Morgan, J., Miller, J.N., McMahon, W.M., Lu, J., Jeong, E.K., and Lainhart, J.E. (2007) Diffusion tensor imaging of white matter in the superior temporal gyrus and temporal stem in autism. Neurosci Lett, 424:127-132.

Lainhart, J.E. (2006) Advances in autism neuroimaging research for the clinician and geneticist. Am J Med Genet C Semin Med Genet, 142:33-39. Review.

Lainhart, J.E., Lazar, M., Bigler, E., and Alexander, A. (2005) The Brain During Life in Autism: Advances in Neuroimaging Research. In: Recent Developments in Autism Research, Ed. M Casanova, NOVA Science Publishers.

Lainhart, J.E. (2003) Increased rate of head growth during infancy in autism. Journal of the American Medical Association, 290:393-394.

Bigler, E.D., Tate, D.F., Neeley, S., Wolfson, L.F., Miller, M.J., Rice, S.A., Cleavenger, H., Anderson, C., Coon, H., Ozonoff, S., Johnson, M., Dinh, E., Lu, J., McMahon, W., and Lainhart, J.E. (2003) Temporal lobe, autism, and macrocephaly. Am J Neuroradiology, Nov-Dec;24(10):2066-2076.

Lainhart, J.E., Ozonoff, S., Coon, H., Krasny, L., Dinh, E., Nice, J., McMahon, W. (2002) Autism, Regression, and the Broader Autism Phenotype. Am J Medical Genetics, 4:1-7.

Lainhart, J. (1999) The psychiatry of autism: disorders in probands and relatives. International Review of Psychiatry, 11:278-298.

Folstein, S.E., Santangelo, S.L., Gilman, S.E., Piven, J., Landa, R., Lainhart, J., Hein, J., and Wzorek, M. (1999) Predictors of cognitive test patterns in autism families. Journal of Child Psychology and Psychiatry, 40:1117-1128.

Lainhart, J.E., Piven, J., Wzorek, M., Landa, R., Santangelo, S., Coon, H., and Folstein, S. (1997) Macrocephaly in children and adults with autism. Journal of the American Academy of Child and Adolescent Psychiatry 36:282-290.

Reviews:
Lainhart, J.E. (1997) Developmental Abnormalities in Autism. Lancet 349:373-374.

Lainhart, J., and Piven, J. (1995) Diagnosis, Treatment and Neurobiology of Autism in Children. Current Opinion in Pediatrics 7:392-400.