|Professor of Psychiatry
Neurobiology of Disease
Brain and Behavior
In vivo neurochemical changes associated with mood and drug abuse disorders; natural products as novel treatments
Perry Renshaw received his M.D. and Ph.D. (biophysics) degrees from the University of Pennsylvania School of Medicine before completing his residency in Psychiatry at the Massachusetts General Hospital in 1992. From 1992-2008, Dr. Renshaw was Research Director and then Director of the McLean Hospital Brain Imaging Center in Belmont, MA. He was also on the faculty of Harvard Medical School, where he became a Professor of Psychiatry in 2003. Dr. Renshaw's research program has been continuously funded by the NIH since 1994. His work is centered on the use of magnetic resonance spectroscopy (MRS) to identify changes in brain chemistry that are associated with mood and substance abuse disorders. These observations are used to identify novel therapies.
Current clinical/MRS trials are focused on the use of citicoline as a treatment for methamphetamine dependence, creatine as a treatment for depression, and uridine as a treatment for bipolar disorder. In addition, the Renshaw laboratory is exploring the surprisingly strong association between suicide rates and altitude of residence. The underlying hypothesis is that brain metabolic changes associated with altitude increase the prevalence and severity of mood disorders.
Kim, N., Wade, J., Brenner, B.E., Haws, C.A., Yurgelun-Todd, D.A., and Renshaw, P.F. (2010) Altitude, gun ownership, rural areas, and suicide. in press.
Yoon, S.J., Lyoo, I.K., Kim, H.J., Kim, T.S., Sung, Y.H., Kim, N., Lukas, S.E., and Renshaw, P.F. (2010) Neurochemical alterations in methamphetamine-dependent patients treated with cytidine-5'-diphosphate choline: a longitudinal proton magnetic resonance spectroscopy study. Neuropsychopharmacology, Apr;35(5):1165-1173.
Allen, P.J., D'Anci, K.E., Kanarek, R.B., and Renshaw, P.F. (2010) Chronic creatine supplementation alters depression-like behavior in rodents in a sex-dependent manner. Neuropsychopharmacology, Jan;35(2):534-546.
Yoon, S.J., Lyoo, I.K., Haws, C., Kim, T.S., Cohen, B.M., and Renshaw, P.F. (2009) Decreased glutamate/glutamine levels may mediate cytidine's efficacy in treating bipolar depression: a longitudinal proton magnetic resonance spectroscopy study. Neuropsychopharmacology, Jun;34(7):1810-1818.
Jensen, J.E., Daniels, M., Haws, C., Bolo, N.R., Lyoo, I.K., Yoon, S.J., Cohen, B.M., Stoll, A.L., Rusche, J.R., and Renshaw, P.F. (2008) Triacetyluridine (TAU) decreases depressive symptoms and increases brain pH in bipolar patients. Exp Clin Psychopharmacol, Jun;16(3):199-206.