Assistant Professor of Pharmacology and Toxicology and Pediatrics
Neurobiology of Disease
Brain and Behavior
Clinical and translational research in traumatic brain injury, post-traumatic epilepsy, and both pathophysiology and management aspects of pediatric neurointensive care
Dr. Statler is a board-certified pediatric intensivist who cares for critically ill children in the Pediatric Intensive Care Unit at Primary Children's Medical Center. Her research includes clinical and translational projects in the fields of traumatic brain injury, post-traumatic epilepsy, and pediatric neurointensive care. Current translational studies focus on traumatic brain injury and the development of post-traumatic epilepsy. Current clinical studies include multi-center investigations of therapeutic hypothermia after pediatric cardiac arrest and the effects of sedation on outcome in critically ill children. Other interests include the application of electrophysiological monitoring and brain imaging techniques to guide management of life-threatening pediatric neurological illnesses, such as traumatic brain injury, status epilepticus, and anoxic brain injury.
Statler, K.D. (2006) Pediatric post-traumatic seizures: epidemiology, putative mechanisms of epileptogenesis, and promising investigational progress. Dev Neurosci, 28(4-5):354-363.
Statler, K.D., Alexander, H., Vagni, V., Holubkov, R., Dixon, C.E., Clark, R.S., Jenkins, L., and Kochanek, P.M. (2006) Isoflurane exerts neuroprotective actions at or near the time or severe traumatic brain injury. Brain Res, 1076(1):216-224.
Statler, K.D., Alexander, H., Vagni, V., Dixon, C.E., Clark, R.S.B., Jenkins, L., and Kochanek, P.M. (2006) Comparison of seven anesthetic agents on outcome after experimental traumatic brain injury in adult, male rats. J Neurotrauma, 23(1):97-108.
Statler, K.D., Janesco, K.L., Melick, J.A., Clark, R.S., Jenkins, L.W., and Kochanek, P.M. (2003) Hyperglycolysis is exacerbated after traumatic brain injury with fentanyl vs. isoflurane anesthesia in rats. Brain Res, 994(1):37-43.
Statler, K.D., Alexander, H., Vagni, V., Nomoto, E., Tofovic, S.P., Dixon, C.E., Jenkins, L.W., Marion, D.W., and Kochanek, P.M. (2003) Moderate Hypothermia may be Detrimental After Traumatic Brain Injury in Fentanyl-Anesthetized Rats. Crit Care Med, 31:1134-1139.
Statler, K.D., Jenkins, L.W., Dixon, C.E., Clark, R.S., Marion, D.W., and Kochanek, P.M. (2001) The simple model versus the super model: translating experimental traumatic brain injury research to the bedside. J Neurotrauma 18:1195-1206.
Hendrich, K.S., Kochanek, P.M., Melick, J.A., Schiding, J.K., Statler, K.D., Williams, D.S., Marion, D.W., and Ho, C. (2001) Cerebral perfusion during anesthesia with fentanyl, isoflurane, or pentobarbital in normal rats studied by arterial spin-labeled MRI. Mag Reson Med, 46:202-206.
Statler, K.D., Kochanek, P.M., Dixon, C.E., Alexander, H.L., Warner, D.S., Clark, R.S.B., Wisneiwski, S.R., Graham, S.H., Jenkins, L.W., Marion, D.W., and Safar, P.J. (2000) Isoflurane improves long-term neurologic outcome versus fentanyl after traumatic brain injury in rats. J Neurotrauma 17:1179-1189.