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This site represents faculty notes on the references cited and in no way is meant as "original" work or as a source for public access. This site is meant to be a private teaching resource for myself and selected students.

 

 

NEUSC 6040      Cellular and Molecular Neuroscience Fall 2008     

 Lecture: MWF 1:15-2:45 Room HSEB 4100C (unless otherwise noted)
NOTE: FINAL EXAM IN ROOM HSEB 4100C ON MONDAY DEC. 15

Organizer:    Alan R. Light    587-4826
Office:  3R438 Anesthesiology  alan.light@hsc.utah.edu

Instructors:

Tatjana Piotrowski

piotrowski@neuro.utah.edu

Neurobiology & Anatomy

7-7638

Introduction: nervous system evolution and structure

 

 

 

Alan R. Light

alan.light@hsc.utah.edu

Anesthesiology and N&B

7-4826

Neuronal cell biology: cytoskeleton, transport, structure

 

 

 

Mary Lucero

Mary.Lucero@utah.edu

Physiology

5-5601

Ion channels: types, structure and function

 

 

 

Kristen Keefe

k.keefe@utah.edu

Pharmacology

5-7989

Receptors: types, structure and function

 

 

 

Eric Jorgensen

Jorgensen@biology.utah.edu

Biology

5-3517

Synaptic function: mechanism of neurotransmission

 

 

 

Karen Wilcox

Karen.Wilcox@hsc.utah.edu

Pharmacology & Toxicology

1-4081

Synaptic Plasticity: activity-dependent change

 

 

 

Villu Maricq

maricq@biology.utah.edu

Biology

1-6318

Ionotropic glutamate receptors

 

 

 

Mike Michel

Mike.Michel@utah.edu

Physiology

5-5420

Neuronal signal transduction: 2nd messengers

Robert Fujinami

robert.fujinami@hsc.utah.edu

Pathology

5-3305

Neurobiology of Disease



Text: From Molecules to Networks: An Introduction to Cellular and Molecular Neuroscience. Byrne and Roberts, Eds. Copies are available in the health sciences bookstore at Heritage Commons. This is a required text (see below). However, students should be aware that much of the material for the course is presented in the lectures and material provided on this site.

Grading: Assignment of grades will be based on three exams (70%) oral presentations and class participation (25%), and timely submission of original (no plagiarism!) abstracts BEFORE presentations (5%). All exams will be given at the times listed on the attached class schedule. Exams will cover the indicated lectures and be written by all participating instructors.

Exam policy: In the interest of fairness, all students will take the exams at the same time in the same room. Make-up exams will be administered with prior arrangement only, usually in advance, and generally only for a serious medical reason, death in the family, or attendance at a scientific meeting. If you have a question concerning the grading of an exam, a written description of your query together with the exam must be resubmitted to the course organizer within one week of receiving the graded exam.

Oral Presentations (Discussion Sections): Each student will present a critical review of a manuscript from the primary literature. The paper will be selected by the instructor for each section and be directly related to the lecture material. Depending on final enrollment, 1-3 students will present during each discussion section (see attached schedule); Each presentation should be approximately 30 minutes long. Oral presentations will be graded and feedback provided by the instructor. Performance on the oral presentation and class participation will count for 25% of the final course grade. This time will also be used as a question period and discussion period with the instructors. Lively interaction and discussion is strongly encouraged and will be factored in to the 25% for oral presentations and class participation. .In addition, ALL students in the class are required to submit a one-page written review abstract of each manuscript being presented (except for the one you are presenting), as well as one question regarding the manuscript, at the beginning of each discussion session. This is for EVERY manuscript other than the one you are responsible for presenting. These submissions will contribute 5% to your overall grade.

Lectures: Information will be presented in the lectures that is not available in the text book or from other sources. In exams, students will be held responsible for all lecture information. It is strongly encouraged that students attend all lectures. Reading from the course text and other sources will be assigned by the instructor during each lecture. In exams, students will be held responsible for all the information in the assigned reading, whether or not it has been specifically addressed in lecture.

Disabilities: The University seeks to provide equal access to its programs, services and activities for people with disabilities. If you will need any accommodations in the class, reasonable prior notice needs to be given to the Center for Disability Services (162 Olpin Union Building, 581-5020; V/TDD). CDS will work with you and the instructor to make arrangements for accomodations. All written information in this course can be made available in alternative format with prior notification to the Center for Disability Services, and the course Director (Dr. Light).

Reviews, Discussion Papers, and Practice Exam Questions, and Discussion Sections



Student Retreat

NO CLASS

M

8/25

 

 

Lecture 1

Piotrowski: Intro I: Evolution

W

8/27

 

1:15-2:45

Lecture 2

Piotrowski: Intro II: Neurons & Glia

F

8/29

 

1:15-2:45

Labor Day

NO CLASS

M

9/01

 

 

Discussion 1

Piotrowski

W

9/03

 

1:15-2:45

Lecture 3

Light: Cell Bio I: Neuron structure

F

9/05

 

1:15-2:45

Lecture 4

Light: Cell Bio II: Cytoskeleton

M

9/08

 

1:15-2:45

Lecture 5

Light: Cell Bio III: Transport

W

9/10

 

1:15-2:45

Discussion 2

Light

F

9/12

 

1:15-2:45

Lecture 6

Lucero: Ion Channels I: Membrane biophysics

M

9/15

 

1:15-2:45

Lecture 7

Lucero: Ion Channels II: Structure and Gating

W

9/17

 

1:15-2:45

Discussion 3

Lucero

F

9/19

1:15-2:45

Lecture 8

Lucero: Ion Channels III: Selectivity

M

9/22

 

1:15-2:45

Lecture 9

Lucero: Ion Channels IV: Modulation/Non-volted-gated

W

9/24

 

1:15-2:45

Lecture 10

Lucero: Ion Channels V: Action Potentials

F

9/26

 

1:15-2:45

Discussion 4

Lucero

M

9/29

 

1:15-2:45

Exam Lectures 1-10

 

W

10/01

 

1:15-2:45

Lecture 11

Jorgensen: Synaptic Transmission I

F

10/03

ASB 210

1:15-2:45

Lecture 12

Jorgensen: Synaptic Transmission II

M

10/06

ASB 210

1:15-2:45

Lecture 13

Jorgensen: Synaptic Transmission III

W

10/08

ASB 210

1:15-2:45

Lecture 14

Jorgensen: Synaptic Transmission IV

F

10/10

ASB 210

1:15-2:45

Semester break

NO CLASS

M-F

10/13-17

 

 

Discussion 5

Jorgensen

M

10/20

ASB 210

1:15-2:45

Discussion ?

W

10/22

1:15-2:45

SNOWBIRD

NO CLASS

F

10/24

 

 

Lecture 16

Keefe: Neurotransmitter synthesis I

M

10/27

 

Lecture 17

Keefe: Neurotransmitter synthesis II

W

10/29

 

Discussion 6

Keefe

F

10/31

 

Exam Lectures 11-17

 

M

11/03

 

1:15-2:45

Lecture 18

Michel: G-Protein Coupled Receptors I

W

11/05

1:15-2:45

Lecture 19

Michel: G-Protein Coupled Receptors II

F

11/07

 

1:15-2:45

Lecture 20

Michel: Ca++ as second messenger

M

11/10

 

1:15-2:45

Lecture 21

Michel: Metabotropic receptors I

W

11/12

1:15-2:45

Lecture 22

Michel: Metabotropic receptors II

F

11/14

 

1:15-2:45

Discussion 7

Michel

M

11/17

 

1:15-2:45

Discussion 8?

Society for Neuroscience Meeting

W

11/19

 

1:15-2:45

Lecture 23

Maricq: Ionotropic ACH-GABA

F

11/21

 

1:15-2:45

Lecture 24

Maricq: Glutamate Receptors-ion channels

M

11/24

 

1:15-2:45

Lecture 25

Maricq: Ionotropic Glutamate Receptors

W

11/26

 

1:15-2:45

Thanksgiving recess

NO CLASS 

F

11/28

 

 

Lecture 26

Maricq:Ionotropic receptors-cell biology

M

12/01

 

1:15-2:45

Discussion 8

Maricq

W

12/03

 

1:15-2:45

Lecture 27

Fujinami

F

12/05

HSEB 5100C 

1:15-2:45

Discussion 9

M

12/08

 

1:15-2:45

Lecture 28

Wilcox: Synaptic Plasiticity I

W

12/10

 

1:15-2:45

Lecture 29

Wilcox: Synaptic Plasticity II 

F

12/12

1:15-2:45

Exam Lectures 18-29

 

M

12/15

 

1:15-2:45