Fergil Mills
Cellular Molecular,
Developmental Neuroscience,
Molecular Neuroscience,
Neurobiology of Disease,
Brain and Behavior
Email:
fergil.mills@neuro.utah.edu
Education
B.S. 2007, University of Northern British Columbia; Ph.D. 2015 University of British Columbia; Postdoc 2019, Massachusetts Institute of Technology; Postdoc Present, Salk Institute for Biological Studies
RESEARCH:
Exploring the neural circuits that underlie learning and behavior
Every day, we have to make sense of sensory stimuli in the world around us. We can
identify things that are rewarding or dangerous based on our learned experience, and
then use this information to choose the correct behavior – a process critical for
survival. A major goal of our lab is to uncover the neural circuits that represent rewards and
threats in the brain, and understand how these circuits act to direct motivated behaviors.
Understanding the neural circuits which mediate learning and motivated behavior is
also of critical importance to mental health: responses to environmental stimuli are
severely disrupted in neurological disorders such as anxiety, depression, and post-traumatic
stress disorder, leading to damaging behavioral outcomes. In order to develop effective
treatments for these disorders, we must first identify the fundamental mechanisms
underlying learning and valence in the brain.
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A key focus of our lab’s research program is the Amygdalostriatal Transition Zone, or “ASt”. The ASt is highly connected with the amygdala, a key structure for emotional learning, and the striatum, which plays a critical role in action selection. However, the role of the ASt in learning and behavior is poorly understood. In our recent work we have found that ASt neurons encode aversive conditioned stimuli, and are both necessary and sufficient to drive defensive behaviors, establishing the ASt as a new structure of interest in the study of motivated behaviors. |
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We are currently working to understand the role of this structure in both learned and innate responses to stimuli. Our lab uses a combination of in vivo calcium imaging, optogenetics, and in vivo electrophysiology, and combines these techniques with deep-learning based computational analysis of behavior in freely-moving mice. |
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The Mills lab is currently recruiting at all levels!
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