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Gary C. Schoenwolf

Distinguished Professor of Neurobiology and Anatomy
Adjunct Professor of Pediatrics
Director, Children's Health Research Institute
Editor-in-Chief, Developmental Dynamics

Developmental Neuroscience
Molecular Neuroscience
Neurobiology of Disease
Cellular Neuroscience

e-mail: schoenwolf@neuro.utah.edu
B.A., 1971, Elmhurst College; M.S., 1973, Ph.D., 1976, University of Illinois; Postdoctoral Fellow, University of New Mexico

RESEARCH:

Pattern formation during early embryogenesis of vertebrates

The Schoenwolf laboratory addresses the general question of how intercellular and intracellular signaling results in the generation of pattern during vertebrate embryogenesis. Although we work on a number of diverse organ rudiments and developmental events using multiple experimental organisms, our current work is focused on normal and abnormal development of the ear. This work is relevant for understanding birth defects, cancer and aging.

Selected Publications:

Schoenwolf, G.C. (2008) Laboratory Studies of Vertebrate and Invertebrate Embryos. Guide and Atlas of Descriptive and Experimental Development, 9th Edition. Prentice Hall, Upper Saddle River, New Jersey. In preparation.

Schoenwolf, G.C. (2007) Larsen's Human Embryology. 4th Edition. Churchill Livingstone, Philadelphia.

Schoenwolf, G.C. (2007) Atlas of Descriptive Embryology, 7th Edition. Prentice Hall, Upper Saddle River, New Jersey.

Chapman, S.C., Cai, Q., Bleyl, S., and Schoenwolf, G.C. (2006) Restricted expression of Fgf16 within the developing chick inner ear. Dev. Dyn., 235:2276-2281.

deCastro, M., Saijoh, Y., and Schoenwolf, G.C. (2006) Optimized cationic lipid-based gene delivery reagents for use in developing vertebrate embryos. Dev. Dyn., 235: 2210-2219.

Chapman, S.C., Lawson, A., MacArthur, W.C., Wiese, R. J., Loechel, R. H., Burgos-Trinidad, M., Wakefield, J.K., Ramabhadran, R., Mauch, T.J., and Schoenwolf, G.C. (2005) Ubiquitous GFP expression in transgenic chickens utilizing a lentiviral vector. Development, 132:935-940.

Ladher, R.K., Wright, T.J., Moon, A.M., Mansour, S.L., and Schoenwolf, G.C. (2005) FGF8 initiates inner ear induction in chick and mouse. Genes Dev., 19:603-613.

Mansour, S., and Schoenwolf, G.C. (2005) Morphogenesis of the inner ear. In: Springer Handbook of Auditory Research, Development of the Ear, D. Wu and M. W. Kelley, Eds. Pp. 43-84.

Wright, T.J., Ladher, R., McWhirter. J., Murre, C., Schoenwolf, G.C., and Mansour, S.L. (2004) Mouse FGF15 is the orthologue of chick FGF19, but is not uniquely required for otic induction. Dev. Biol., 269:264-275.

Kirby, M.L., Lawson, A., Stadt, H.A., Kumiski, D.H., Wallis, K.T., McCraney, E., Waldo, K.L., Li, Y.-X., and Schoenwolf, G.C. (2003) Prechordal plate gives rise to the midline endoderm of the foregut: A potential ventral midline organizer. Dev. Biol., 253:175-188.

Schoenwolf, G.C., and Mathews, W.W. (2003) Atlas of Descriptive Embryology, 6th Edition. Prentice Hall, Upper Saddle River, New Jersey. 8-1/2 X 11"; 280 pages; 299 illustrations.

Chapman, S.C., Schubert, F.R., Schoenwolf, G.C., and Lumsden, A. (2002) Analysis of spatial and temporal gene expression patterns in blastula and gastrula stage chick embryos. Dev. Biol., 245:187-199.

Healy, K.H., Schoenwolf, G.C., and Darnell, D.K. (2001) Cell interactions responsible for notochord induction and differentiation in the chick embryo. Dev. Dynamics, 222:165-177.

Schoenwolf, G.C. (2001) Cutting, Pasting and Painting: Contributions of experimental embryology to the study of neural development. Nature Rev. Neurosci., 2:763-771.

Schoenwolf, G.C. (2001) Laboratory Studies of Vertebrate and Invertebrate Embryos. Guide and Atlas of Descriptive and Experimental Development, 8th edition. Prentice Hall, Upper Saddle River, New Jersey, 8-1/2 X 11"; 360 pages; 487 illustrations.

Darnell, D.K., Stark, M.R., and Schoenwolf, G.C. (1999) Timing and cell interactions underlying neural induction in the chick embryo. Development, 126:2505-2514.

Yuan, S., and Schoenwolf, G.C. (1999) Reconstitution of the organizer is both sufficient and required to re-establish a fully-patterned body plan in avian embryos. Development, 126:2461-2473.

Yuan, S., and Schoenwolf, G.C. (1998) De novo induction of the organizer and formation of the primitive streak in an experimental model of notochord reconstitution in avian embryos. Development, 125:201-213.

Smith, J.L., and Schoenwolf, G.C. (1998) Getting Organized: New Insights into the Organizer of Higher Vertebrates. In: Current Topics in Developmental Biology. Vol. 40. Eds., R.A. Pederson and G.P. Schatten. Academic Press, Inc., Orlando, pp. 79-110.

Smith, J.L., and Schoenwolf, G.C. (1997) Neurulation: Coming to closure. Trends Neurosci., 20:510-517.

Schoenwolf, G.C. (1997) Embryo: CD Color Atlas for Developmental Biology. Prentice Hall, Englewood Cliffs, New Jersey. CD-ROM with about 900 photographs, movies and animations plus demo CD-ROM with selected images.

 

Last Updated: 2/22/17